IDDI Speaker at EFSPI Meeting
June 4, 2019
Precision Medicine in Drug Development
The Basel Biometric Section (BBS) and the European Federation of Statisticians in the Pharmaceutical Industry (EFSPI) host a European scientific meeting on Precision Medicine in Drug Development topic. The purpose is to bring together experts from the pharmaceutical industry, academia and the European regulatory bodies to present the current state of the art and discuss the challenges and opportunities ahead.
Tomasz Burzykowski, VP Research, IDDI Speaker at EFSPI will present ‘Generalized pairwise comparisons for precision medicine‘
Abstract: A novel statistical approach to the analysis of randomized clinical trials uses all pairwise comparisons between two patients, one in the treatment arm and one in the control arm. Each pair favors treatment (“win”), control (“loss”), or neither. The “net treatment benefit” is the difference between the proportion of wins minus the proportion of losses. Pairwise comparisons can incorporate several outcomes of interest and several thresholds of clinical relevance in the analysis, and as such, they can be used to personalize treatment choices and to assess the benefit/risk of randomized therapeutic interventions in a rigorous yet flexible manner.