IDDI actively participates in research in the fields of biostatistics and clinical epidemiology. IDDI collaborates with major academic institutions, research groups and clinical groups, including:
- Association Européenne de Recherche en Oncologie (AERO) Créteil, France: Phase II and phase IV trials in early rectal, early and advanced breast cancer
- Breast International Group (BIG), Brussels, Belgium: Phase III trial in early breast cancer
- Cancer International Research Group (CIRG), Edmonton (Canada) and Paris, France: Phase III trials in early and advanced cancer

- Cleveland Clinic Coordinating Center for Clinical Research (C5 Research), Cleveland, USA: IDMC Statistical support for cardiovascular trials
- European Organization for Research and Treatment of Cancer (EORTC), Brussels, Belgium: Meta-analysis of advanced breast cancer trials
- Institut Jules Bordet, Brussels, Belgium: Meta-analysis of trials in advanced breast cancer
- Nagoya University
- Hasselt University ,Diepenbeek, Belgium: Validation of surrogate endpoints in clinical trials, analysis of longitudinal data, statistical methods for meta-analysis
- Meta-Analysis Group In Cancer (MAGIC), Créteil, France: Meta-analyses in colorectal, breast, ovarian and oesophageal cancer, and melanoma
- National Surgical Adjuvant Breast and Bowel Project (NSABP) Pittsburgh, USA: Phase II trials in oncology
- TRANSBIG, Brussels, Belgium: collaborative project for a clinical trial using molecular profiling of patients with early breast cancer, a project funded by the European Unio
- Fédération Francophone de Cancérologie Digestive FFCD: PETACC 8 trial, analyses to explore Cetuximab as adjuvant to therapy of colorectal cancer.
- European Institute of Oncology, Milan : Validation of genomic signature